• EE 428/528 BioMEMS & Lab-on-a-chip, Lecture, 3 credits

• Covers various commonly used micro/nanofabrication techniques, microfluidics, various chemical and biochemical applications such as separation, implantable devices, drug delivery, and microsystems for cellular studies and tissue engineering. Discusses recent and future trends in BioMEMS and nanobiosensors. Students will gain a broad perspective in the area of micro/nano systems for biomedical and chemical applications.

• Fall 2007

• M/W/F, 9:00 AM - 9:50 AM, 209 NORTON

• Kwang W. Oh, Ph.D. (kwangoh@buffalo.edu)

• SMALL (nanobio Sensors and MicroActuators Learning Lab), http://www.SMALL.buffalo.edu

• Department of Electrical Engineering, University at Buffalo

• 215E Bonner Hall, North Campus, Buffalo, NY 14260

• Office Hours: Wed 10:00 AM – 12:00 AM or by appointment

• Graduate standing in engineering, medicine, biomedical sciences, and natural sciences or

• Senior undergraduate students (with permission only from the instructor)

• By the end of the course, students should be able to:

1. Review BioMEMS fabrication

2. Identify miniaturization issues on life sciences

3. Review various microfluidic platforms

4. Demonstrate creative solutions at the interface of biology and technology

• Class notes and Handouts. Course website will be announced when it is ready.

• Stefan Haeberle and Roland Zengerle, Microfluidic platforms for lab-on-a-chip applications,  Lab Chip, 2007 DOI: 10.1039/b706364b Critical Review

• Reyes D R, Iossifidis D, Auroux P–A and Manz A Micro total
  (articles) analysis systems: 1. Introduction, theory, and technology Anal. Chem. 74 2623–36, 2002

• Auroux P–A, Iossifidis D, Reyes D R and Manz A Micro total analysis systems: 2. Analytical standard operations and applications Anal. Chem. 74 2637–52, 2002

• Vilkner T, Janasek D and Manz A Micro total analysis systems: recent developments Anal. Chem. 76 3373–86, 2004

• uPetra S. Dittrich, Kaoru Tachikawa, and Andreas Manz 2006 Micro Total Analysis Systems. Latest Advancements and Trends Anal. Chem. 78, 3887-3908, 2006

• Oh K W and Ahn C H 2006 A review of microvalves J. Micromech. Microeng. 16 R13–R39

• A. Manz, H. Becker, Microsystem Technology in Chemistry and Life Sciences, Springer, 1999

• O. Geschke, H. Klank, and P. Telleman, Microsystem Engineering of Lab-on-a-chip Devices, John Wiley & Sons, 2nd Edition, 2004

• G. T. A. Kovacs, Micromachined Transducers Source Book, MacGraw-Hill, 1998

• N. –T. Nguyen, S. Wereley, Fundamentals and Applications of Microfluidics, Artech House Publishers, 2002

• EE 428: Presentation 40%, Attendancy 10%, Midterm 25%, Final 25%

• EE 528: Presentation & Attendancy 40%, Paper 10%, Midterm 25%, Final 25%

Presentation & Paper

• 1. Weekly Presentation (for EE 428/528): Pick two random nouns from a dictionary. Each noun must begin with the same letter that begins your last and first name. For example, Kwang W. Oh would choose nouns that begin with the letter ¡°K¡± and ¡°O¡±. Now, add micro-, nano-, or bio- to the beginning of the noun, and speculate on any potential usefulness of the technology or application. Identify at least one critical research issue related to each case. Each Friday class, 3~4 students present their works, approximately 15 min long. The grading (instructor: 50%, students: 50%) will be based on the uniqueness, originality of your selections, and presentation skills.

• 2. Presentation Workshop (for EE 428/528): Choose a BioMEMS/LOC system/device/application; Come up with a solution of a device/system that the students might think works better than existing solutions; All students present the following assignments, approximately 15 min long; The grading (instructor: 50%, students: 50%) will be based on the creativeness, originality of your selections, and presentation skills.

• 3. Paper (for only EE 528): Choose a BioMEMS/LOC system/device/application and write a short review paper (~10 pages with 12-point type single spaced with 1-inch margins including figures, tables, and references). Paper will be due toward the end of the term (12/07/2007). Both a print-out version and an electronic one are required. Please do not choose the following categories: microvalve, micropump, micromixer.

The schedule is subject to change and changes to the published schedule will be announced in class.

Now all 25 lecture notes are publicly downloadable, and this was supported by NSF grant (NSF-ECCS-0736501).
 

Week	Lecture	Date	Title
1	[01]	08/27 M	Syllabus / Introduction to MEMS
	[02]	08/29 W	Introduction to BioMEMS
	[03]	08/31 F	Introduction to NanoBiosensors
2		09/03 M	No Class. Labor Day Observed
	[04]	09/05 W	MEMS Fabrication
	[05]	09/07 F	BioMEMS Fabrication 1
3	[06]	09/10 M	BioMEMS Fabrication 2
	[07]	09/12 W	Miniaturization in the Life Sciences 1
	[08]	09/14 F	Miniaturization in the Life Sciences 2
4	[09]	09/17 M	Microfluidics
	[10]	09/19 W	Capillary-driven Microfluidics
		09/21 F	Weekly Presentation 1
5	[11]	09/24 M	Pressure-driven Microfludiics
	[12]	09/26 W	PDMS-Based Integrated Fluidic Circuits
		09/28 F	Weekly Presentation 2
6	[13]	10/01 M	Centrifugal-driven Microfluidics
	[14]	10/03 W	Electrokinetic-driven Microfluidics
		10/05 F	Weekly Presentation 3
7	[15]	10/08 M	Electrowetting-based Microfluidics
	[16]	10/10 W	Droplet-based / SAW-based Microfluidics
		10/12 F	Weekly Presentation 4
8		10/15 M	Mid Term
	[17]	10/17 W	Microvalve
		10/19 F	Weekly Presentation 5
9	[18]	10/22 M	Micropump
	[19]	10/24 W	Microfluidics Components
		10/26 F	Weekly Presentation 6
10	[20]	10/29 M	Cells in Microfluidics 1
	[21]	10/31 W	Cells in Microfluidics 2 / PCR
		11/02 F	Weekly Presentation 7
11	[22]	11/05 M	MicroPCR
	[23]	11/07 W	Drug Delivery / Implantation Devices
		11/09 F	Weekly Presentation 8
12	[24]	11/12 M	Neural Interfaces / Tissue Engineering
	[25]	11/14 W	Point-of-Care Test (POCT)
		11/16 F	Weekly Presentation 9
13		11/19 M	Final Exam
		11/21 W	No Class. Fall Recess & Thanksgiving
		11/23 F	No Class. Fall Recess & Thanksgiving
14	[26]	11/26 M	World-to-Chip Interfacing
	[27]	11/28 W	Recent and future trends Presentation Workshop 1
		11/30 F	Presentation Workshop 2
15		12/03 M	Presentation Workshop 3
		12/05 W	Presentation Workshop 4
		12/07 F	Presentation Workshop 5

• Proposed Syllabus