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Fall 2006
EE 528
BioMEMS & Nanobiosensors

  Proposed Syllabus

Time & Location

  • Fall 2006

  • M/W/F, 9:00 AM - 9:50 AM, 115 BALDY
Instructor

  • Kwang W. Oh, Ph.D., SMALLab (nanobioSensors and MicroActuators Learning Lab), Department of Electrical Engineering

  • 215E Bonner Hall, kwangoh@buffalo.edu

  • Office Hours: Wed 10:00 AM – 12:00 AM or by appointment
Prerequisites

  • Graduate students in engineering and natural sciences or

  • Senior undergraduate students (with permission from the instructor)
Objectives

  • The field of BioMEMS and Nanobiosensors has seen tremendous growth in the past several years. The lab-on-a-chip (LOC) concept and its applications will be introduced. Various micro/nanofabrication techniques that are commonly used in BioMEMS and Nanobiosensors will be taught. Microfluidics, which is the foundation for most of the applications, will be covered followed by the various chemical and biomedical applications such as separation, implantable devices, drug delivery, and microsystems for cellular studies and tissue engineering. Recent and future trends in BioMEMS and nanobiosensors will be discussed too. Students will gain a broad perspective in the area of micro/nano systems for biomedical and chemical applications.
Textbooks

  • Class notes and Handouts. Course website will be announced when it is ready.
References
Grading

  • Combination of Homework and Attendance (HA) / Project (Paper and/or Presentation) / Midterm Exam (ME) / Final Exam (FE)

  • 1. Graduates: HA 20%, Paper 20%, Presentation 20%, ME 20%, FE 20%

  • 2. Undergradutes: HA 25%, Presentation 25%, ME 25%, FE 25%
Projects

  • 1. Paper:

    • *Choose a BioMEMS/Nanobiosensor system/device/application and write a short review paper (15~20 pages with 12-point type single spaced with 1-inch margins including figures, tables, and references). Paper will be due toward the end of the term (12/06). Both a print-out version and an electronic one are required.
    • Please do not choose the following categories:
      • Microvalve
      • Micropump
      • Micromixer
    •

  • 2. Presentation:

    • Pick five random nouns from a dictionary. Each noun must begin with the same letter that begins your last name. For example, Kwang W. Oh would choose nouns that begin with the letter ¡°O¡±. Now, add micro- or nano- to the beginning of the noun, and speculate on any potential usefulness of the technology or application. Identify at least one critical research issue related to each case. Presentation will occur during the second half of the term, approximately 7 minutes long. The grading will be based on the uniqueness, originality of your selections, and presentation skills.
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Schedule

The schedule is subject to change and changes to the published schedule will be announced in class.
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Week

 Lecture

Date

Title
1 [01] 08/28 M  Syllabus / Introduction to MEMS 
¡¡ [02] 08/30 W  Introduction to BioMEMS 
¡¡ [03] 09/01 F   Introduction to NanoBiosensors
2 ¡¡ 09/04 M  No Class. Labor Day Observed 
[04] 09/06 W   MEMS Fabrication
[05] 09/08 F  BioMEMS Fabrication 1 
3 [06] 09/11 M  BioMEMS Fabrication 2 
¡¡ [07] 09/13 W  Miniaturization in the Life Sciences 
¡¡ [08] 09/15 F  Microfluidics 
4 [09] 09/18 M  Capillary-driven Microfluidics 
[10] 09/20 W  Pressure-driven Microfludiics 
[11] 09/22 F  PDMS-Based Integrated Fluidic Circuits 
5 [12] 09/25 M  Centrifugal-driven Microfluidics 
¡¡ [13] 09/27 W  Electrokinetic-driven Microfluidics 
¡¡ [14] 09/29 F  Electrowetting-based Microfluidics 
6 ¡¡ 10/02 M  No Class. Yom Kippur 
[15] 10/04 W Plug-based / SAW-based Microfluidics 
[16] 10/06 F Microvalve 
7 [17] 10/09 M  Micropump 
¡¡ [18] 10/11 W   Microfluidics Components
¡¡ ¡¡ 10/13 F UB Closed due to the October Surprise Storm
8 ¡¡ 10/16 M   UB Closed due to the October Surprise Storm
[19] [20] 10/18 W  Drug Delivery Devices / Implantable Devices 
[20] [21] 10/20 F  Implantable Devices / Neural Interfaces / Tissue Engineering
9 ¡¡ 10/23 M  Midterm Exam
¡¡ [22] [23] 10/25 W  Cells in Microfluidics 1 / Cells in Microfluidics 2
¡¡ [24] 10/27 F  MicroPCR
10 [25] 10/30 M  Point-of-Care Test (POCT)
[26] 11/01 W  World-to-Chip Interfacing and Packaging
[27] 11/03 F  Biosensors
11 ¡¡ 11/06 M  No Class. Out-of-campus for uTAS 2006 Conf 
¡¡ ¡¡ 11/08 W  No Class. Out-of-campus for uTAS 2006 Conf 
¡¡ ¡¡ 11/10 F  No Class. Out-of-campus for uTAS 2006 Conf 
12 [28] 11/13 M  Electrochemical Sensors / BioFET
[29] 11/15 W  Nanostructure-based Biosensors
[30] 11/17 F Nanoparticles for Biosensing
13 [31] 11/20 M  Magnetic Biosensors
¡¡ ¡¡ 11/22 W  No Class. Fall Recess & Thanksgiving 
¡¡ ¡¡ 11/24 F  No Class. Fall Recess & Thanksgiving 
14 ¡¡ 11/27 M  Class Presentation 
¡¡ 11/29 W  Class Presentation 
¡¡ 12/01 F  Class Presentation 
15 ¡¡ 12/04 M  Class Presentation 
¡¡ [32] 12/06 W  Class Presentation 
Recent and future trends in BioMEMS & Nanobiosensors
¡¡ ¡¡ 12/08 F  Final Exam 

¡¡
Homeworks --> Gradings and solutions are on UBLearns!!!
Materials

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