GS FLX and FLX TITANIUM SERIES

"The FLX 454 Genome Sequencer System accelerates the pace of discovery in diverse fields of biology", including those of marine biology, drug discovery, cancer and infectious disease research, and many more.

Examples of the diverse studies that use the FLX technology include HIV sequencing, the analysis of ancient DNA, metagenomics and microbial diversity.

The following are a few of the publication that utilize FLX genomic sequencing:

Cancer Research

Transcriptome sequencing to detect gene fusions in cancer.  Maher C, Kumar-Sinha C, Cao X, Kalyana-Sundaram S, Han B, Jing X, Sam L, Barrette T, Palanisamy N & Chinnaiyan AM. (2009) Nature ePub:
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Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing.  Campbell PJ, Pleasance ED, Stephens PJ, Dicks E, Rance R, Goodhead I, Follows GA, Green AR, Futreal PA, Stratton MR. (2008) PNAS 105: 13081-6
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Somatic mutations affect key pathways in lung adenocarcinoma.  Ding L et al. (2008) Nature 455: 1069-75
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Evolution and Ecology

Complete Mitochondrial Genome Sequence of the Tyrolean Iceman.  Luca Ermini, Cristina Olivieri, Ermanno Rizzi, Giorgio Corti, Raoul Bonnal, Pedro Soares, Stefania Luciani, Isolina Marota, Gianluca De Bellis, Martin B. Richards and Franco Rollo (2008) Current Biology 18: 1-7
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Biodiversity and biogeography of phages in modern stromatolites and thrombolites  Desnues C, Rodriguez-Brito B, Rayhawk S, Kelley S, Tran T, Haynes M, Liu H, Furlan M, Wegley L, Chau B, Ruan Y, Hall D, Angly FE, Edwards RA, Li L, Thurber RV, Reid RP, Siefert J, Souza V, Valentine DL, Swan BK, Breitbart M, Rohwer F (2008) Nature 452: 7185
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Systems Biology

Microarray and cDNA sequence analysis of transcription during nerve-dependent limb regeneration.  Monaghan JR, Epp LG, Putta S, Page RB, Walker JA, Beachy CK, Zhu W, Pao GM, Verma IM, Hunter T, Bryant SV, Gardiner DM, Harkins TT, Voss SR. (2009) BMC Biology 7: 1
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Human Genetics

Use of pyrosequencing and DNA barcodes to monitor variations in Firmicutes and Bacteroidetes communities in the gut microbiota of obese humans.  Armougom F, Raoult D. (2008) BMC Genomics 9: 576
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Simultaneous mutation and copy number variation (CNV) detection by multiplex PCR-based GS-FLX sequencing.  Goossens D, Moens LN, Nelis E, Lenaerts AS, Glassee W, Kalbe A, Frey B, Kopal G, Jonghe PD, Rijk PD, Del-Favero J. (2008) Human Mutations ePub:
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Click here for the complete list of publication using the FLX Sequencing technology

Contact Information

Infectious Disease and Genomics
Lab(B3-124)
701 Ellicott St.
Buffalo, NY 14203
Phone: 716-881-7514
Fax: 716-849-6655
Email: email IDG lab