Third Year Medicine Clerkship

Medical Ethics Syllabus Chapter

CASE #1

	A 91 year old woman was brought to the emergency 
room because of syncope.  She lost consciousness at the 
adult home where she resides.  In the ER, she was noted 
to be minimally responsive, and had a heart rate of 30 
bpm; her BP was barely palpable.  She was treated with IV 
atropine and isoproterenol.  Her heart rate and BP 
stabilized, and she became more alert.  Cardiology 
consultant recommended placement of a permanent 
pacemaker.  The patient was advised of this, and did not 
voice any objection to a pacemaker.  Her mental status 
and level of consciousness at the time was noted as: " 
awake, lethargic, quiet; somewhat confused".

	A short time later, the patient's son arrived.  He 
was noted by the nurses to be "belligerent, with a 
hostile attitude".  He announced that he was the 
patient's only relative, and that furthermore, he was her 
"proxy".  He presented a copy of her Health Care Proxy 
(naming him as health care agent), and demanded that she 
NOT have a pacemaker.  He stated that his mother was 
"obviously incompetent", and that he should be making her 
medical decisions.

QUESTIONS:

1.	What is the usual process for making medical 
decisions?  Which parties are ordinarily involved in 
the decision making process, and what roles do each 
of them play?  How does that model apply to this 
case?

2.	Is this patient capable of making medical decisions? 
 Who should determine whether or not a patient is 
capable?  How does one go about making that 
determination?  If the patient is not capable, how 
are decisions made?

3.	What is the difference between competence and 
decision making capacity?  What are the implications 
and consequences of this difference?



REFERENCES:

Appelbaum PS, Grisso T. Assessing Patients' Capacities to 
Consent to Treatment. N Engl J Med 1988; 319:1635-8.

Hansen-Flaschen JH. In the Best Interests of Helga 
Wanglie (Editorial). Hospital Practice 1992; Feb. 28. pp. 
8-12.

Seckler AB, Meier DE, Mulvihill M, Paris BE. Substituted 
judgment: how accurate are proxy predictions? Ann Int Med 
1991; 115(2):92-8.

President's Commission for the Study of Ethical Problems 
in Medicine and Biomedical and Behavioral Research 
(1983). Deciding to forego life-sustaining treatment: 
ethical, medical, and legal issues in treatment 
decisions. Washington, D.C.: U.S. Government Printing 
Office.

President's Commission for the Study of Ethical Problems 
in Medicine and Biomedical and Behavioral Research 
(1982): Making Health Care Decisions: the ethical and 
legal implications of informed consent in the patient-
practitioner relationship, Washington, D.C., U.S. 
Government Printing office, vol. 1: report.

The New York State Task Force on Life and the Law (1987): 
Life Sustaining Treatment: making decisions and 
appointing a health care agent.

The New York State Task Force on Life and the Law (1992): 
When Others Must Choose: deciding for patients without 
capacity. 



CASE #2

	A 62 year old woman was admitted in status 
epilepticus.  Her respiratory status was compromised and 
she required intubation and ventilation.  She had a past 
history which was positive for Hodgkins Disease (6 year 
ago; presently in remission), and lung cancer which was 
fully resected 1 year ago.

	She was weaned from the ventilator over the next few 
days, and began to slowly improve.  Her mental status was 
noted to fluctuate widely.  Whe was largely incoherent, 
with occasional "lucid intervals."  During one of those 
intervals she was asked about life-sustaining treatments, 
and reportedly told the housestaff to "do everything".   
Much of the time however, she was described by the 
housestaff as, "incompetent to make decisions."

	After 3 days, the patient's respiratory status again 
deteriorated, and the physicians contemplated re-
intubation.  By this time, the patient's daughter arrived 
from out of town, and brought in a copy of the patient's 
"Living Will" (signed by the patient 10 years ago).  She 
also had a "Power of Attorney" (prepared one year ago) 
naming that daughter as "Attorney in Fact".  She demanded 
that her mother NOT be re-intubated.


QUESTIONS:

1.	What means do competent adults have to influence the 
future medical care that is provided to them after 
they have lost the capacity to make decisions?  What 
is the difference between an "Instructional 
Directive" and a "Proxy Directive"?

2.	What is the legal status of Living Wills in New York 
State?  What about other advance directives? 

3.	What decision making powers are delegated in a Power 
of Attorney?
		...a Durable Power of Attorney?
		...a Durable Power of Attorney for Health Care?
		...a Health Care Proxy?

4.	How do you interpret a patient's request to: "do 
everything", if they do not elaborate?  Since 
consent to treatment must be informed, what kinds of 
discussions could clarify such a blanket request?  

5.	How do you resolve the apparent conflict between a 
patient who wants "everything", and a relative who 
wants to limit treatment?  Does it make any 
difference 
		...that the patient was vague in her statement? 
 
		...that she was intermittantly confused, and 
possibly "incompetent"?  
		...that the relative has some legal 
authorization to make (at least some type of) 
decisions for the patient?   
		...that the authorization does not specifically 
refer to health care decisions?  

6.	Some patients and families are concerned about 
getting "stuck" on a ventilator for indefinite 
periods of time.  Do you share this concern?  Is the 
only way to avoid this outcome to forego intubation 
in the first place?  


7.	Is there any ethical or philosophical difference 
between a.) withholding life sustaining treatment, 
and b.) starting it but withdrawing it later?  
...any legal difference?  ...any psychological 
difference?


REFERENCES:

Barnett TJ. Limiting specific interventions in advanced 
directives. JAMA 1992; 267(1):51-2. 

Emanuel L. Advance directives: what have we learned so 
far?. J Clin Eth 1993; 4(1):8-16.

Emanuel EJ, Emanuel LL. Proxy decision making for 
incompetent patients. An ethical and empirical analysis. 
JAMA 1992; 267(15):2067-71.

Greco PJ, Schulman KA, Lavizzo-Mourey R, Hansen-Flaschen 
J. The Patient Self-Determination Act and the Future of 
Advance Directives. Ann Int Med 1991; 115:639-643.

La Puma J, Orentlicher D, Moss RJ. Advance directives on 
admission; Clinical implications and analysis of the 
Patient Self-Determination Act of 1990". JAMA 1991; 
266(3):402-5.

Lynn J. Procedures for making medical decisions for 
incompetent adults. JAMA 1992;
267(15):2082-4.


CASE #3

	A 78 year old man was diagnosed with prostate cancer 
4 years ago.  It has metastasized to his bones and lungs. 
 He has developed progressive bone pain as well as lung 
congestion and shortness of breath.  He presented to the 
hospital with fever, and probably urinary tract 
infection.  He was successfully treated with antibiotics, 
but complained of worsening pain.  

	He was given IV morphine with "minimal relief."   
The housestaff documented that he was still in severe 
pain at the "maximum dose of morhine".  They also 
reported that his breathing has become "slow and 
shallow", while still remaining in pain.  
  
QUESTIONS:

1.	Is it appropriate to give further opioid, with the 
knowledge that it will likely suppress his 
respirations further?  Are we then "responsible for 
his death"?

2.	How does opioid use for terminal pain (which 
hastens death) differ from euthanasia or assisted 
suicide?  

CASE #3 (Cont.):

	The patient was given more morphine with 
considerable relief of his pain.  His breathing remained 
shallow, but adequate.  Over the next 24 hours however, 
he became more tachypneic and anxious.  He cried out that 
he was "suffocating".  

QUESTIONS (Cont.):

3.	What alternatives can you provide for relief of the 
patient' symptoms?

4.	Advances in knowledge about pain management and 
palliative care have actually demonstrated that 
concerns about respiratory depression are often 
exagerated when treating pain.  This is NOT the case 
when treating severe dyspnea.  While morphine 
clearly relieves severe dyspnea, it will frequently 
suppress respiratory drive and result in a sooner 
death.  Is this acceptable?   


REFERENCES:

Berry ZS, Lynn J. Hospice medicine. JAMA 1993; 
270(2):221-3.

Wanzer SH, Adelstein SJ, Cranford RE, et al. The 
physician's responsibility toward hopelessly ill 
patients. N Engl J Med 1984; 310:955-959.

Wanzer SH, Federman DD, Adelstein SJ, et al. The 
physician's responsibility toward hopelessly ill 
patients: a second look. N Engl J Med 1989; 320:844-849.
CASE 4.

	A 90 year old female was admitted to a Buffalo area 
hospital with abrupt unconsciousness 4 weeks ago.  
Neurology diagnosed "massive brainstem stroke".  She had 
previously lived in a nursing home.  Her only close 
relative is a son who is named health care agent in a 
Health Care Proxy the patient prepared last year.   At 
present (4 weeks following admission), she remains 
unresponsive, and the neurologists offer little hope of 
further significant improvement.  She has received IV 
fluids, but the son has objected to any enteral feeds.  A 
review of the Proxy reveals no statements about feeding 
tubes, but the son emphatically states that he and his 
mother had discussed this in the past.


QUESTIONS:

1.	Are enteral feeding tubes different from other kinds 
of medical treatment?  Does anyone have the 
authority to refuse feeding tubes for another 
individual?  ...for themselves?

2.	Are enteral feeds "ordinary" or "extraordinary" 
care?  Is this distinction helpful in making 
decisions about such care?  How does one go about 
categorizing a particular treatment modality in this 
schema?

3.	Is there any relevant distinction between the IV and 
the proposed enteral feeding tube?  Is it ever 
appropriate to discontine all nutrition and 
hydration?  If so, under what circumstances?

REFERENCES:

Sullivan RJ. Accepting Death without Artificial Nutrition 
and Hydration. J Gen Intern Med 1993; 8:220-224 (with 
editorial:225-226).

Scofield GR. Artificial feeding: the least restrictive 
alternative? J Am Ger Soc 1991; 39(12):1217-20. 

Meyers RM, Grodin MA. Decisionmaking regarding the 
initiation of tube feedings in the severely demented 
elderly: a review. J Am Ger Soc 1991; 39(5):526-31.











CASE #5.

	A 66 year old man with longstanding COPD was 
admitted with pneumonia.  He was treated with IV 
antibiotics, inhaled bronchodilators, and nasal oxygen.  
A DNR consent from his out-patient chart was brought to 
the hospital and a DNR order was signed.  Over the next 
12 hours, he became more dyspneic.  Arterial blood gas 
analysis demonstrated rising CO2, and falling pO2.  The 
nurse called the resident on call, who felt the patient 
required urgent intubation.  The resident then noted the 
DNR order in the chart, and asked if the patient was 
"DNI" as well.  None of the nursing staff or housestaff 
were certain.  They tried to discuss it with the patient, 
who was stuporous by this time.  They placed a call to 
the attending physician's answering service who said they 
would page him and give him the message to return the 
call.



QUESTION/DISCUSSION:
How is "DNR" different from "DNI"?

1.)	DNR is a precise instruction (defined by NYS law) 
directing us NOT to provide a specific therapy (CPR) in 
the event of a certain situation (cardio-respiratory 
arrest).  DNI can mean different things to different 
people, in different situations.

2.)	The DNR process and algorithm is dictated by the DNR 
Law.  Although it is based upon societal values and 
practices, its details derive from its legal status.  
Thus, a relative on the DNR surrogate list might make a 
DNR decision simply by weighing burdens and benefits 
(best interests standard).  In the absence of a Proxy, 
all other non-treatment decisions (including non-code 
intubation) must be based upon the patient's previously 
stated wishes.  

	The DNR documentation for surrogates is also 
dictated by law.  Similar looking forms for "DNI" carry 
no legal authority (except at the VA, which is not 
subject to New York State laws). 

3.)	The probability of successful CPR is well defined 
and can be succinctly presented to a patient or surrogate 
in advance of a cardiac arrest occurring.  There are a 
large number of published reports which demonstrate:

a.	CPR usually does not restore heartbeat 
(approximately 1/3 of codes in cumulative data).

b.	Of those who do survive initially, only 1/3 leave 
the hospital alive.

	This cumulative data includes diverse groups of 
patients:  Acute MIs on monitor do much better than this, 
and chronically ill patient with cancer or multi-system 
disease arresting on a general medical floor, do much 
worse.  The cumulative data can therefore, be further 
refined to apply to the individual patient in a very 
specific way.  DNR/CPR discussions can therefore be 
relatively precise. 

	In contrast, there are very few patients for whom
such accurate predictions can be made concerning 
successfully weaning them from the ventilator following 
urgent (but pre-arrest) intubation and ventilation.  
Attempting such discussions in advance require a fair 
amount of conjecture concerning weanablity.  In fact, the 
question of weanability is best answered once weaning is 
attempted.  If there are fears about "getting stuck on 
the vent", explicit time limits or a Health Care Proxy 
are the best protections, and will permit a relatively 
comfortably extubation at a later time.  Remember, 
withholding and withdrawing are (generally) morally and 
legally equivalent; if you feel you might not be 
justified in extubating a vent-dependent patient, you 
probably would not have been justified in withholding 
intubation and ventilation. 

4.)	CPR is a discrete, relatively brief treatment, for a 
condition (cardiac arrest) which usually occurs with 
little or no warning.  Renal, cardiac, and CNS injury 
often result from the cardiovascular collapse of a full 
arrest.  The treatment is completed when it either 
successfully restores heartbeat, or it is deemed a failed 
attempt.  In either case, it rarely lasts longer than an 
hour (often much less). Furthermore, once it is "successful", 
there is no  way to reverse the decision.  Therefore, the only 
effective means to forego CPR and avoid its sequelae, is 
to decline it in advance of the cardiac arrest.  

	Intubation and mechanical ventilation however, are 
often initiated after a period of respiratory decline 
lasting minutes to hours; damage to other organ systems 
is rare.  Once begun, mechanical ventilation can usually 
be maintained for extended periods of time.  Therefore, 
most patients intubated for respiratory failure can be 
stabilized and reevaluated after treatment has been 
initiated.  Often the uncertainty of clinical situations
make it difficult to predict the patient's response in
advance of this therapeutic trial.

	There is tremendous heterogeneity in clinical 
situations leading to (non-arrest) intubation/ventilation.
These range from bronchospasm or pneumonia to end-stage 
heart failure, COPD or lung cancer.  People who are 
intubated for milder reversible problems often do quite
well after a few days of support.  Those with severe
irreversible disease predictably do poorly and may 
never be successfully weaned.

	In the absence of severe irreversible disease, 
patients who decline (non-arrest) intubation/ventilation 
need to understand the probability of a good outcome.
The potential for (undesired) prolonged ventilation still 
exists, but this is better managed with a health care proxy 
or explicit time limits on a therapeutic trial.


	Often there is too much attention being paid to 
advance decisions to withhold  ventilation in questionable 
cases.  I'm not referring to lung mets, PVS, and other extreme 
examples, but to cases  in which there is a suspicion that the 
patient may be difficult to wean.  In such cases, it seems that 
students and housestaff are hung up on "getting the DNI order" 
so they will not have to intubate where there is a chance 
the patient might not get off later.  One of my concerns 
is that this really represents a "withhold/withdraw" 
bias, in which the student or resident has no hesitation 
to withhold ventilation from someone they would never 
remove from a ventilator.

	Unlike CPR/DNR decisions, there is often no pressing 
need to decide about other treatments in advance, since 
they can always be discontinued later, following a trial 
of therapy.  Certainly some people with clearly thought 
out wishes and attitudes may elect to forego a variety of 
treatments in advance.  Those individuals should be 
encouraged to discuss and formalize those wishes.  Most 
people however, who do not have such clear ideas, are 
better served by executing a Health Care Proxy, naming 
someone they trust to make decisions when they become 
incapacitated. 

	In other cases, a particular complication is so 
predictable, and untreatable (such as respiratory failure 
with lung mets), that it really ought to be discussed in 
advance.  This must however, be in the context of a 
comprehensive treatment plan.  Such conversations should 
focus on the overall plan to best benefit the patient 
(such as adequate palliative treatment).  A patient with 
progressive dyspnea from lung cancer, is likely to be 
more concerned about what you will do to relieve the 
suffocation he fears his dying will bring, than he is 
whether you will try to extend his life with a vent.   
Patients appreciate frank and open discussions when they 
are directed toward the patient's particular needs and 
concerns.

REFERENCES:

Blackhall LJ. Must We Always Use CPR? N Engl J Med 1987; 
317:1281-1285.

Council on Ethical and Judicial Affairs, American Medical 
Association.  Guidelines for the Appropriate Use of Do-
Not-Resuscitate Orders.  JAMA 1991; 265:1868-1871.

Schonwetter RS, Walker RM, Kramer DR, Robinson BE.  
Resuscitation Decision Making in the Elderly: the value 
of outcome data.  J Gen Intern Med 1993; 8:295-300.


	If questions remain concerning DNR/DNI, or if you 
believe there is something here which is clearly 
different from what you have been told elsewhere, please 
let me know.  Call any time, or better yet, leave me a 
message on E-mail 

Jack P. Freer, MD
887-4852 (leave recorded message)
887-4600 (page)






CASE 6.

	A 78 year old woman was admitted 5 weeks ago with aphasia and
right hemiparesis.  She was initially treated with TPA with little
improvement.  Within the first week, she developed worsening neurologic
symptoms and was felt to have suffered a second CVA.  During the second
hospital week, she developed atrial fibrillation and hypotension.  She
required intubation and mechanical ventilation.  

At the present time, she is totally unresponsive to all stimulus
(including deep pain).  She has diminished, but not totally absent cranial
nerve reflexes.  She has shown no progress in the ensuing weeks, and the
neurologists believe she suffered diffuse cerebral anoxic damage, in
addition to the discrete cerebral infarcts. She remains on the ventilator
for apparent ARDS.  

Her husband is her only close relative and has indicated he believes she
will get better and come home with him.  He has steadfast refused any
limitation of medical treatment including CPR.  There is no Health Care
Proxy and the husband has provided no reports of the patient's prior
wishes.  

QUESTIONS:

1. Are there any treatments currently provided (or anticipated) that would
be considered "futile?" Explain the way in which they are futile.

2.	If there are any such futile treatments, what are the implications
for decision making?  Who is authorized to make futility determinations
and why?

2. Is the patient receiving life-sustaining treatments that are not
(strictly speaking) futile, but are still inadvisable, inappropriate, or
otherwise evidence of faulty decision making?  On what grounds?

3. What is the relevance of the husband's inability to recount any patient
wishes or statements?  How would it matter if he told of her desire to
have her life prolonged at all costs?  How would it matter if he told of
her distaste for life-sustaining treatment?






REFERENCES:

Baker R. The ethics of medical futility. Crit Care Clin 1993; 9(3):575-84.

Caplan AC. Odds and Ends: Trust and the Debate over Medical Futility. Ann
Int Med 1996; 125:688-689. 

Fins JJ. Futility in clinical practice: report on a Congress of Clinical
Societies. J Am Ger Soc 1994; 42(8):861-5.

Jecker NS, Pearlman RA. Medical Futility: who decides? Arch Int Med 1992;
152:1140-1144.

Lantos JD, Singer PA, Walker RM et al. The Illusion of Futility in Medical
Practice. Am J Med 1989; 87:81-84.

Schneiderman LJ, Jecker NS, Jonsen AR. Medical Futility: its meaning and
ethical implications. Ann Int Med 1990; 112(12):949-54.

Tomlinson T, Brody H. Futility and the Ethics of Resuscitation. JAMA 1990;
264:1276-1280.

Youngner SJ. Applying futility: saying no is not enough. . J Am Ger Soc
1994; 42(8):887-9.














	MEDICAL DECISION MAKING PROCESS

Informed consent/refusal
Decision making standards for incapacitated patients:
	--prior decision while competent
	--substituted judgment standard
	--best interest standard
Surrogate decision making
Medical futility
Decision making capacity vs. competence
Decisions to forego life sustaining treatment
Artificial hydration and nutrition


TEXTBOOK REFERENCES



REVIEW ARTICLES

Baker R. The ethics of medical futility. Crit Care Clin 
1993; 9(3):575-84.

Jackson DL, Youngner S. Patient Autonomy and "Death with 
Dignity": some clinical caveats. N Engl J Med 1979; 301: 
404-408.

Jecker NS, Pearlman RA. Medical Futility: who decides? 
Arch Int Med 1992; 152:1140-1144.

Lantos JD, Singer PA, Walker RM et al. The Illusion of 
Futility in Medical Practice. Am J Med 1989; 87:81-84.

Miller BL. Autonomy & the Refusal of Lifesaving 
Treatment. Hast Cent Rep Aug 1981; 12:22-28.

Schneiderman LJ, Jecker NS, Jonsen AR. Medical Futility: 
its meaning and ethical implications. Ann Int Med 1990; 
112(12):949-54.

Singer PA, Siegler M. Elective Use of Life-sustaining 
Treatments in Internal Medicine. Adv Int Med 1991; 
36:57-79.

Tomlinson T, Brody H. Futility and the Ethics of 
Resuscitation. JAMA 1990; 264:1276-1280.

Truog RD, Brett AS, Frader J. The Problem with Futility. 
N Engl J Med 1992; 326:1560-1564.



The following excerpt is an excellent review of the 
subject of surrogate decision making.  It is from The New 
York State Task Force on Life and the Law (1992): When 
Others Must Choose: deciding for patients without 
capacity.  It is found on pages 54-58 of this report: 

 
Ethical Guideposts for Surrogate Decisions

	A broad consensus has emerged over the past decade 
supporting two standards for surrogate decision making: 
formulating a "substituted judgment" as to what the 
patient would have decided, and choosing in accord with 
the patient's "best interests."  Respect for personal 
autonomy undergirds the substituted judgment standard, 
while the obligation to promote the patient's well-being 
in more objective terms forms the basis of the best 
interests standard.

The Substituted Judgment Standard

	The substituted judgment standard requires the 
surrogate to make decisions about treatment according to 
the patient's own values, personal preferences, and 
goals: in effect, to decide in the same way as the 
patient would if he or she were capable.  Many sources of 
information help to guide the surrogate's exercise of 
substituted judgment, ranging from information about the 
patient's treatment preferences in particular 
circumstances to more general knowledge about the 
patient's moral and religious values.  The substituted 
judgment standard has generally been favored by courts as 
well as commentators for those cases in which it is 
applicable. The subjective and personalized perspective 
takes the patient's own values and views of well-being 
into account, and seeks to promote the patient's 
self-determination.

	Although the substituted judgment standard is widely 
recognized and relied upon, frequent application of the 
standard has also served to highlight its limitations.  
While some commentators have posed the theoretical 
problem of whether one can truly know what a formerly 
competent individual, now incompetent, would choose, 
criticism more often focuses on claims that the standard 
has been applied inappropriately in some cases and that 
it simply offers no guidance in others.  Even with 
previously competent patients, application of the 
substituted judgment standard is often somewhat 
speculative.  Many have criticized courts in several 
cases for stretching the limits of substituted judgment 
when the basis for deciding what the patient would have 
chosen was actually quite limited.  This propensity to 
justify decisions under an expansive notion of 
substituted judgment has led some commentators to caution 
that the standard is so elastic that it may lead to poor 
decisions.

	Attempts to apply the substituted judgment standard 
are even more problematic for individuals who have never 
been competent, such as Joseph Saikewicz, a 67-year-old 
profoundly retarded man who was dying of leukemia.  In 
the Saikewicz case, the court held that chemotherapy 
could be withheld, relying on a finding that Mr. 
Saikewicz would have chosen this course of treatment for 
himself if he were "competent but taking into account the 
present and future incompetency of the individual" 
[Superindendent of Belchertown State School v. Saikewicz, 
373 Mass. 728, 370 N.E.2d 417 (1977)].  Most commentators 
agree that for adults who have never been competent, and 
for children who have not yet developed the opportunity 
to arrive at and communicate their decisions or personal 
values, the substituted judgment standard simply offers 
no guidance.

 The Best Interests Standard

	When little or no evidence of the patient's wishes 
is available, the most widely embraced guidepost for 
surrogate decisions is the best interests standard.  
Unlike a substituted judgment, which focuses on the 
patient's known preferences in seeking to infer what the 
patient would have wanted, the best interests standard 
relies to a greater extent upon objective criteria; it 
serves primarily to protect and promote the well-being of 
vulnerable patients.  The best interests standard is 
often understood to reflect a societal consensus, or the 
perspective of a "reasonable person," choosing as most 
people would choose for themselves.

	Many commentators urge that under the best interests 
standard, the surrogate should weigh the benefits and 
burdens of treatment as objectively as possible.  In 
assessing the patient's interests, the surrogate should 
consider the potential goals of treatment in the context 
of the patient's particular circumstances.  Possible 
benefits that should be weighed include the prolongation 
of life, the alleviation of pain and suffering, and the 
preservation or restoration of function.  Treatment 
"burdens" involve the pain, risk, degree of invasiveness 
of medical interventions, and the possibility of 
needlessly prolonging the dying process.  According to 
most commentators, the burden or discomfort of the 
patient's ongoing condition should also be taken into 
account.

	Some commentators urge that the best interests of 
the patient should be identified by taking the view of a 
hypothetical average "reasonable person" in the patient's 
circumstances and deciding about treatment as we believe 
most people would decide for themselves.  Others believe 
that we must, to the best of our ability, vicariously 
assume the perspective of the particular individual.  For 
example, these commentators suggest that a life of 
profound handicap and mental retardation might be wnrth 
living from the perspective of one who has known no other 
condition, even if it might not seem worth living to 
others.

	There is obvious potential for tension and conflict 
among the values pivotal to determining best interests.  
It may be difficult to decide what constitutes or 
contributes to the patient's overall well-being in par-
ticular circumstances. In some situations, treatment may 
preserve or prolong the patient's life, but at the cost 
of burdening the patient with pain or suffering.  
Alternatively, effective doses of pain relief may risk 
hastening the patient's death.  In other cases, the 
treatment itself may not cause the patient discomfort, 
but may sustain the patient's life in circumstances that 
offer no hope for recovery or possibility for human 
interaction or awareness.

	A determination of best interests often rests upon 
basic understandings about the nature and meaning of 
human life.  What qualities of human life do we cherish? 
 How do we affirm our caring and basic human commitments 
to one another at life's end?  Diverse values, often 
shaped by religious and moral beliefs, have been embraced 
as central to the best interests standard.  Indeed, in 
our pluralistic society? we do not share a single vision 
of the best possible outcome for patients in many 
circumstances; the broad concepts of benefits and burdens 
of treatment are identified and weighed differently.

	Sanctity of life and quality of life.  Some 
commentators, often identified as emphasizing "sanctity 
of life," believe that continued life is an intrinsic and 
personal good and that the limitations or burdens imposed 
by illness must always be weighed in that light.  In one 
formulation of this position: "No matter how burdened it 
may be, human life remains inherently a good of the 
person. Thus, remaining alive is never rightly regarded 
as a burden" [May WE: "Feeding and Hydrating the 
Permanently Unconscious and Other Vulnerable Persons," 
Issues in Law and Medicine (1987) 3:205].

	According to this viewpoint, an assessment of 
benefits and burdens that fails to value continued 
biological life as an unambiguous good shifts the ethical 
focus of treatment decisions to unacceptable judgments 
about the quality of the life preserved.  For these 
commentators, burdensomeness should be assessed by 
focusing on the pain or invasiveness caused by the 
treatment itself, not by evaluating the quality of life 
that such medical intervention may sustain.  Hence, if a 
treatment such as antibiotics is minimally invasive and 
has limited or no side effects, it should be provided to 
sustain a patient's life regardless of the quality of 
that life.  Proponents of sanctity of life also argue 
that quality-of-life judgments threaten to undercut 
societal commitments to the preservation of life and the 
protection of vulnerable persons.

	Other commentators view life as a basic and precious 
good, but one that is valued principally as a 
precondition for other higher goods, such as experience, 
thought, and human interaction.  Sustained biological 
function is not regarded as a goal in and of itself, 
apart from the patient's overall condition and the 
benefits or burdens that continued life may offer to the 
patient.  According to this view, discontinuing 
treatment, even if it leads to the patient's death, is 
consistent with his or her best interests when the 
treatment is hopeless and serves only to sustain 
biological existence that is painful or of no benefit to 
the patient.  As expressed by one commentator, "Medicine 
has traditionally refused to make prolognation of life 
its goal, not only because the goal was finally 
unreachable, but also because it recognized that efforts 
in that direction often produced more harm than good - in 
pain and discomfort as well as anguish and anxiety" [Kass 
LR: "Ethical dilemmas in the Care of the Ill: what is the 
patient's good?" JAMA (1980) 244:1947].












	BRAIN DEATH AND SEVERE CNS INJURY

Determination of death
Death by whole brain criteria
Neocortical death
Persistent vegetative state


TEXTBOOK REFERENCES



REVIEW ARTICLES



Bernat JL, Culver CM, and Gert B. On the Definition and 
Criterion of Death. Ann Int Med 1981; 94:389-384.

Black P McL. Brain Death. N Engl J Med 1978; 299:334-344. 

Halevy A, Brody B. Brain Death: reconciling definitions, 
criteria, and tests. Ann Int Med 1993; 119(6):519-25.

Olick RS. Brain Death, Religious Freedom, and Public 
Policy: New Jersey's landmark legislative initiative. 
Kenn Inst Eth J 1991; 1:275-288.

Truog RD,  Fackler JC. Rethinking Brain Death. Crit Care 
Med 1992; 20(12):1705-13.

Veatch RM. The Impending Collapse of the Whole-Brain 
Definition of Death. Hast Cent Rep Jul-Aug 1993; 
23(4):18-24.















	EMERGENCY/CRITICAL CARE

Do not resuscitate orders
intubation and mechanical ventilation
ventilator withdrawal
Withholding treatment vs. withdrawal of treatment
 


TEXTBOOK REFERENCES



REVIEW ARTICLES


ACCP/SCCM Consensus Panel. Ethical and Moral Guidelines 
for the Initiation, Continuation and Withdrawal of 
Intensive Care. Chest 1990; 97:949-958.

Adams J, Wolfson AB. Ethical Issues in Geriatric 
Emergency Medicine. Emer Med Clin  No Amer 1990; 8(2): 
183-92.

American Thoracic Society. Withholding and Withdrawing 
Life-sustaining Therapy. Ann Int Med 1991; 115:478-485.  
{also appears in: Am Rev Resp Dis 1991; 144:727-732.}


Council on Ethical and Judicial Affairs, American Medical 
Association.  Guidelines for the Appropriate Use of Do-
Not-Resuscitate Orders. JAMA 1991; 265:1868-1871.

Edwards BS, Ueno WM. Sedation Before Ventilator 
Withdrawal. J Clin Eth 1991; 2: 118-122.

Task Force on Ethics of the Society of Critical Care 
Medicine. Consensus Report on the Ethics of Foregoing 
Life-sustaining Treatments in the Critically Ill. Crit 
Care Med 1990; 18:1435-1439.

Wachter RM, Luce JM, Hearst N, Lo B. Decisions about 
Resuscitation: Inequities among Patients with Different 
Diseases but Similar Prognoses. Ann Int Med 1989; 
111:525-532.









	LEGAL ISSUES

 


TEXTBOOK REFERENCES


REVIEW ARTICLES

Greco PJ, Schulman KA, Lavizzo-Mourey R, Hansen-Flaschen 
J. The Patient Self-determination Act and the Future of 
Advance Directives. Ann Int Med 1991; 115:639-643.

Meisel A. Legal Myths About Terminating Life Support. 
Arch Int Med 1991; 151:1497-1502.

Meisel A. The legal consensus about forgoing life-
sustaining treatment: its status and its prospects. Kenn 
Inst Eth J 1992; 2:309-345.

Veatch RM. Forgoing Life-Sustaining Treatment: Limits to 
the consensus. Kenn Inst Eth J 1993; 3:1-19.

The following guidebooks are available from:

		The New York State Health Department
		Box 2000
		Albany, NY  12220
or
		The New York State Task Force on Life and the 
Law
		5 Penn Plaza, 3rd Floor
		New York, NY  10001-1803

New York State Department of Health, The New York State 
Task Force on Life and the Law (1991): The Health Care 
Proxy Law: a guidebook for health care professionals. 

Medical Society of the State of New York, New York State 
Department of Health, Hospital Association of New York 
State (1992): Do Not Resuscitate Orders: questions and 
answers for health care professionals (second edition).