Basic Concepts

Essential Terms & Concepts

Receptor Binding Simulations

Single Ligand Receptor Binding

Ligands with Different Affinities

Ligand Displacement by a Competitive Antagonist

Ligand Displacement by a Noncompetitive Antagonist

Distinguishing Binding Sites from Receptors

Binding sites are not always equivalent to receptor sites. Only binding sites that are linked with some biological action are considered receptors. Other tissue sites may bind drug but produce no biological action (e.g., lipid and protein binding). Some substances even bind ligands with the characteristics usually associated only with receptor-binding sites (e.g., opioid binding to glass wool fibers). But true receptor binding has several properties not associated with nonreceptor binding sites. These properties form the criteria that must all be met to consider a binding site a true receptor site.

Copyright 1999 Michael A. Bozarth
This page was last updated 04 November 1999 03:29 EDT
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