Pharmacokinetic Principles
Simulation of an Open Two-Compartment Model



 
Simulation Parameters
QT = 10 k12 = 0.5 k21 = 0.2 k10 = 0.1
Time Q1 Q2 Qe F12 F21 F10
0 10.0000 0.0000 0.0000 5.0000 0.0000 1.0000
1 4.0000 5.0000 1.0000 2.0000 1.0000 0.4000
2 2.6000 6.0000 1.4000 1.3000 1.2000 0.2600
3 2.2400 6.1000 1.6600 1.1200 1.2200 0.2240
4 2.1160 6.0000 1.8840 1.0580 1.2000 0.2116
5 2.0464 5.8580 2.0956 1.0232 1.1716 0.2046
6 1.9902 5.7096 2.3002 0.9951 1.1419 0.1990
7 1.9380 5.5628 2.4993 0.9690 1.1126 0.1938
8 1.8877 5.4192 2.6931 0.9439 1.0838 0.1888
9 1.8389 5.2792 2.8818 0.9195 1.0558 0.1839
10 1.7914 5.1429 3.0657 0.8957 1.0286 0.1791
11 1.7451 5.0100 3.2449 0.8726 1.0020 0.1745
12 1.7001 4.8806 3.4194 0.8500 0.9761 0.1700
13 1.6561 4.7545 3.5894 0.8281 0.9509 0.1656
14 1.6134 4.6317 3.7550 0.8067 0.9263 0.1613
15 1.5717 4.5120 3.9163 0.7858 0.9024 0.1572
16 1.5311 4.3954 4.0735 0.7655 0.8791 0.1531
17 1.4915 4.2819 4.2266 0.7458 0.8564 0.1492
18 1.4530 4.1713 4.3758 0.7265 0.8343 0.1453
19 1.4154 4.0635 4.5211 0.7077 0.8127 0.1415
20 1.3789 3.9585 4.6626 0.6894 0.7917 0.1379
21 1.3433 3.8563 4.8005 0.6716 0.7713 0.1343
22 1.3086 3.7566 4.9348 0.6543 0.7513 0.1309
23 1.2747 3.6596 5.0657 0.6374 0.7319 0.1275
24 1.2418 3.5650 5.1931 0.6209 0.7130 0.1242
25 1.2097 3.4729 5.3173 0.6049 0.6946 0.1210
26 1.1785 3.3832 5.4383 0.5892 0.6766 0.1178
27 1.1480 3.2958 5.5561 0.5740 0.6592 0.1148
28 1.1184 3.2107 5.6710 0.5592 0.6421 0.1118
29 1.0895 3.1277 5.7828 0.5447 0.6255 0.1089
30 1.0613 3.0469 5.8917 0.5307 0.6094 0.1061
31 1.0339 2.9682 5.9979 0.5170 0.5936 0.1034
32 1.0072 2.8915 6.1013 0.5036 0.5783 0.1007
33 0.9812 2.8168 6.2020 0.4906 0.5634 0.0981
34 0.9558 2.7441 6.3001 0.4779 0.5488 0.0956
35 0.9311 2.6732 6.3957 0.4656 0.5346 0.0931
36 0.9071 2.6041 6.4888 0.4535 0.5208 0.0907
37 0.8837 2.5368 6.5795 0.4418 0.5074 0.0884
38 0.8608 2.4713 6.6679 0.4304 0.4943 0.0861
39 0.8386 2.4074 6.7540 0.4193 0.4815 0.0839
40 0.8169 2.3453 6.8378 0.4085 0.4691 0.0817
41 0.7958 2.2847 6.9195 0.3979 0.4569 0.0796
42 0.7753 2.2256 6.9991 0.3876 0.4451 0.0775
43 0.7552 2.1681 7.0766 0.3776 0.4336 0.0755
44 0.7357 2.1121 7.1521 0.3679 0.4224 0.0736
45 0.7167 2.0576 7.2257 0.3584 0.4115 0.0717
46 0.6982 2.0044 7.2974 0.3491 0.4009 0.0698
47 0.6802 1.9526 7.3672 0.3401 0.3905 0.0680
48 0.6626 1.9022 7.4352 0.3313 0.3804 0.0663
49 0.6455 1.8530 7.5015 0.3227 0.3706 0.0645
50 0.6288 1.8052 7.5660 0.3144 0.3610 0.0629

ChartObject Chart 1

Last Updated on 10/26/99
By Addiction Research Unit
Email: bozarth@buffalo.edu