Chapter 5 (& Appendix B) Study Guide

Key Concepts

• descriptions of the experimental procedures for each of the primary methods of assessing drug reinforcement
• distinction among direct, indirect, interactive, and correlative methods of assessing drug reinforcement
• limited-access testing
• unlimited-access testing
• unit dose
• stable patterns of responding during intravenous drug self-administration
• inter-response times
• mean hourly drug intake
• behavioral compensation during intravenous self-administration tests
• regulation of psychomotor stimulant intake
• progressive-ratio testing
• effect of unit-dose manipulations on psychomotor stimulant intake
• effect of unit-dose manipulations on opioid intake
• effect of saline substitution on intravenous drug self-administration
• lack of tolerance to the reinforcing effects of prototypic addictive drugs
• effects of low- and high-dose naltrexone administration on intravenous opioid self-administration
• effects of low- and high-dose neuroleptic administration on intravenous psychomotor stimulant self-administration
• extinction pattern

Sample Questions

• Which method has been proposed as an animal model of human drug craving?
• Which method tests animals in the drug-free state?
• Which method is best for detecting potentially reinforcing drug effects that are delayed by tens of minutes from the time of drug self-administration?
• Which method is the worse for detecting potentially reinforcing drug effects that are delayed by tens of minutes from the time of drug self-administration?
• What does the failure of hallucinogens to support intravenous self-administration suggest about their reinforcing properties?
• What does the failure of marijuana to support intravenous self-administration suggest about its reinforcing properties?
• What does the failure of alcohol to support intravenous self-administration suggest about its reinforcing properties?