Addiction Research Unit
Department of Psychology/University at Buffalo

Methods of Assessing the Reinforcing Properties of Abused Drugs,

edited by M.A. Bozarth (Publisher: Springer-Verlag, New York, 1987).

Important note: Material online is currently being edited and not in final form. Updates will be posted as available. Use the reload/refresh button on your browser to make certain that you are viewing the most recent version. To receive automatic notification when this and other pages are updated, send your e-mail address and request ARUupdates.
Web-Enhanced Version
This online version has several enhanced features not available in the printed copy of the book. First, the web site search engine can be used to search the entire contents of the book. Second, hyperlinks to referenced chapters have been added. Third, three components are being developed as study aids for use in university course instruction: (1) a short Drug Glossary which provides information about some of the compounds studied in the book, (2) an Experimental Procedure Glossary which provides brief descriptions of some of the experimental procedures, and (3) samples of recent publications illustrating the application of these techniques. 
Search Engine Instructions for Searching
Drug Glossary
Experimental Procedures Glossary
Applications of the Experimental Procedures


Table of Contents

Foreword (Michael A. Bozarth)

Self-Administration Studies

Chapter 1: Intravenous self-administration: Response rates, the effects of pharmacological challenges, and drug preferences. Robert A. Yokel.

Chapter 2: Screening for drug reinforcement using intravenous self-administration in the rat. James R. Weeks & R. James Collins.

Chapter 3: Assessing drugs for abuse liability and dependence potential in laboratory primates. J. R. Brady, R. R. Griffiths, R. D. Hienz, N. A. Ator, S. E. Lukas, & R. J. Lamb.

Chapter 4: Interpretation of lesion effects on stimulant self-administration. D. C. S. Roberts & K. A. Zito.

Chapter 5: Second-order schedules of drug reinforcement. Jonathan L. Katz & Steven R. Goldberg.

Chapter 6: Intravenous drug self-administration: A special case of positive reinforcement. Roy A. Wise.

Chapter 7: Oral drug self-administration: Drugs as reinforcers. Richard A. Meisch & Marilyn E. Carroll.

Chapter 8: Oral self-administration of alcohol: A valid approach to the study of drug self-administration and human alcoholism. Z. Amit, B. R. Smith, & E. A. Sutherland.

Chapter 9: Intracranial self-administration procedures for the assessment of drug reinforcement. Michael A. Bozarth.

Chapter 10: Prediction of drug abuse liability from animal studies. Tomoji Yanagita.

Conditioning Studies

Chapter 11: Conditioned reinforcement as a measure of the rewarding properties of drugs. W. Marvin Davis & Stanley G. Smith.

Chapter 12: Reinstatement of drug-taking behavior as a method of assessing the incentive motivational properties of drugs. Jane Stewart & Harriet de Wit.

Chapter 13: Place conditioning: A simple and effective method for assessing the motivational properties of drug. Derek van der Kooy.

Chapter 14: Conditioned place preference: A parametric analysis using systemic heroin injections. Michael A. Bozarth

Chapter 15: Anatomical and neurochemical substrates of drug reward determined by the conditioned place preference technique. Anthony G. Phillips & Hans C. Fibiger.

Drug Discrimination Studies

Chapter 16: Applications and limitations of the drug discrimination method for the study of drug abuse. Donald A. Overton.

Chapter 17: Drug discrimination: Methods of manipulation, measurement, and analysis. Francis C. Colpaert.

Chapter 18: The study of structure-activity relationships using drug discrimination methodology. Richard A. Glennon & Richard Young.

Brain Stimulation Reward Studies

Chapter 19: Tests involving pressing for intracranial stimulation as an early procedure for screening likelihood of addiction of opioids and other drugs. Larry D. Reid.

Chapter 20: Brain-stimulation reward: Measurement and mapping by psychophysical techniques and quantitative 2-[14C] deoxyglucose autoradiography. Ralph U. Esposito, Linda J. Porrino, & Thomas F. Seeger.

Chapter 21: A comparison of two methods designed to rapidly estimate thresholds of rewarding brain stimulation. George Fouriezos & Edward Nawiesniak.

Chapter 22: A multifunctional on-line brain stimulation system: Investigation of alcohol and aging effects. Michael J. Lewis & Richard W. Phelps.

Chapter 23: Combined microinjection and brain stimulation reward methodology for the localization of reinforcing drug effects. Chris L. E. Broekkamp.

Assessment in Humans

Chapter 24: Addiction Research Center Inventory (ARCI): Measurement of euphoria and other drug effects. Charles A. Haertzen & John E. Hickey.

Chapter 25: Operant analysis of human drug self-administration: Marihuana, alcohol, heroin, and polydrug use. Nancy K. Mello & Jack H. Mendelson.

Chapter 26: A drug preference procedure for use with human volunteers. H. de Wit & C. E. Johanson.

Chapter 27: Clinical procedures for the assessment of abuse potential. Jack E. Henningfield, Rolley E. Johnson, & Donald R. Jasinski.

Other Considerations

Chapter 28: Operationalizing and measuring the organizing influence of drugs on behavior. Normal M. White, Claude Messier, & Geoffrey D. Carr.

Chapter 29: The mouse as a subject in the study of neural mechanisms of reward. Hugh E. Criswell.

Chapter 30: An overview of assessing drug reinforcement. Michael A. Bozarth.

Mental Health Net 3-Star AwardBook contents copyright © 1987 Springer-Verlag.
This material may not be reproduced without written permission.
Report technical problems to: ARUwebmaster.

ARU home page | ARU Profile | Addiction Primer | Biological Basis | Research Findings
Research Reports | University Courses | Opportunities | Feedback