Research interest is in the area of pharmaceutical biotechnology, in particular lipid nano/microparticulate mediated delivery of biotechnology derived products such as therapeutic proteins and siRNA.

Current research projects:

1. Development of lipidic nano particle containing therapeutic proteins and is supported by NHLBI/NIH. The overall goal of the project is to develop less immunogenic and long acting therapeutic proteins to improve safety and efficacy of protein based products. We adopt multidisciplinary approach involving Biophysics, immunology and pharmacokinetics/Pharmacodynamics.
2. Re-activating Memory T Cells in the Microenvironment of Human Tumors and development of in situ vaccination. This project is supported by NCI/NIH ((Dr. Bankert, PI, Balu-Iyer Co-PI). Our aim is to develop lipidic Microparticulates containing therapeutics such as IL-12 that can reverse TCR arrest using Biophysical, immunological and Toxico kinetics approaches.
3. Design lipid based particle to overcome three distinct barriers in si RNA delivery that include (a) Improve in vivo stability; (b) Target organs and cell type and (c) Facilitate intracellular delivery.
4. Formulation and delivery of Monoclonal antibody based products: We adopt rational strategies based on protein folding approaches to develop stable and efficacious formulations for monoclonal antibody based products.