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> List of Faculty/Staff
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Robert M. Straubinger
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| Pharmaceutical Sciences |
Director of Pharmaceutical Sciences Instrumentation Facility, Professor
539 Cooke Hall
Amherst NY 14260
Phone: (716) 645-2844
Fax: (716) 645-3693
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Website: http://pharmsci.buffalo.edu/~rms/
Email: rms@Buffalo.EDU
Dr. Straubinger‘s research program involves the application of drug carriers for the treatment of infectious diseases and cancer. Current efforts are directed toward improving the therapy of brain tumors (as well as others) by targeting tumor blood vessels. We employ a variety of experimental approaches, including high-resolution magnetic resonance imaging, liquid chromatography/mass spectroscopy, confocal fluorescence microscopy and image analysis, pharmacokinetic/dynamic analysis, and molecular techniques such as quantitative RT-PCR. With these techniques, we examine the effects of treatment upon tumor vascular permeability and drug deposition, the localization of the carrier-delivered drug within the tumor, and the molecular mechanisms involved when tumor blood vessels are attacked during therapy.
Additional interests of the lab that are being pursued actively include understanding the mechanisms of anti-cancer drug action and how they may be modified by changing exposure profile (time vs. concentration). Both genomic and proteomic analysis approaches are utilized in this work.
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