Michael S. Hudecki

Muscle Disease; Instruction to Non-Science Majors

Research Professor
and
Executive Officer Department of Biological Sciences

Ph.D., 1973, University at Buffalo
Postdoctoral work, 1972-1978, Syracuse University & University at Buffalo
Research Assistant Professor, 1978;
Research Associate Professor, 1987, University at Buffalo
Research Professor, 1997; Executive Officer, 1999

Address Information

Michael S. Hudecki
Department of Biological Sciences
109 Cooke Hall
State University of New York at Buffalo
Buffalo, NY 14260

(716) 645-2363 ext: 104

To send e-mail: hudecki@acsu.buffalo.edu

RESEARCH SUMMARY

For several years, Dr. Michael S. Hudecki has conducted research on the etiology and treatment of inherited muscular dystrophy. Utilizing the dystrophic chicken and mouse models as an in vivo framework various pharmacologic entities were tested for potential therapeutic efficacy. Through the efforts of Ms. Catherine Pollina-Loretz and former graduate student, Dr. Joseph Granchelli, a working hypothesis for the etiology of muscle disease has been developed. Specifically, the dystrophic muscle fiber appears to be weakened from a missing protein called dystrophin, hence normal muscle usage causes intramuscular activation of wound/repair/inflammatory responses and the progressive deterioration of the muscle fiber leading to clinical disability. Future study may involve inhibiting components of the inflammatory insult to the muscle fiber to arrest the degradative process (e.g., steroids). More recently, Dr. Hudecki has been active in developing case studies which can be used in his undergraduate non-science major course entitled: Perspectives in Human Biology (www.biology.buffalo.edu/courses/bio129 or bio130).

PUBLICATIONS

• Hudecki, M.S., Pollina, C., Granchelli, J.A., Daly, M.K., Byrnes, T., Wang, J.C. and Hsiao, J.C. (1993)
  Strength and endurance in the therapeutic evaluation of prednisolone-treated mdx mice.
  Res. Commun. Chem. Pathol. Pharmacol. 79:45-60.

• Hudecki, M.S., Povoski, S., Gregorio, C.C., Granchelli, J.A. and Pollina, C. (1995)
  Efficacy of drug regimen exceeds electrostimulation in the treatment of avian muscular dystrophy.
  J. Appl. Physiol. 78:2014-2019.

• Granchelli, J.A., Avosso, D., Hudecki, M.S. and Pollina, C. (1996)
  Cromolyn increases strength in exercised mdx mice.
  Res. Commun. Chem. Pathol. Pharmacol.

• Granchelli, J.A., Pollina, c., and, Hudecki, M.S(2000)
  Gene testing using the mdx mouse model
  J. Neuromuscular Disease, 10: 235-239

• Hudecki, M.S. (20001)
  Kim Davis- Can a genetic disease be cured? A mother's dilemma
  J. College Science Teaching 30: 12-16

• Hartel, J.V., Granchelli, J.A., Hudecki, M.S., Pollina, C.S., and Gosselin, L.E. (2001)
  Impact of prednisone on TGF-b and collagen in diaphragm muscle from mdx mice
  Muscle News 24: 428-432

• Hudecki, M.S. (2001)
  Alzheimer's Disease Case Study - more with little? Use of newspaper articles as case study tools in Human Biology Classroom.
  J. College Science Teaching (in press)

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